Ceramide mediates growth inhibition of the Plasmodium falciparum parasite
Identifieur interne : 002123 ( Main/Exploration ); précédent : 002122; suivant : 002124Ceramide mediates growth inhibition of the Plasmodium falciparum parasite
Auteurs : I. Pankova-Kholmyansky [États-Unis] ; A. Dagan [États-Unis] ; D. Gold [États-Unis] ; Z. Zaslavsky [États-Unis] ; E. Skutelsky [États-Unis] ; S. Gatt [États-Unis] ; E. Flescher [États-Unis]Source :
- Cellular and Molecular Life Sciences CMLS [ 1420-682X ] ; 2003-03-01.
English descriptors
Abstract
Abstract.: In mammalian cells, ceramide mediates death by chemotherapeutic drugs. We analysed, for the first time, the role of ceramide in inhibiting growth of the malaria-causing parasite Plasmodium falciparum. Added exogenously, ceramide significantly decreased the number of parasites, and this effect was abolished by sphingosine-1-phosphate, a biological antagonist of ceramide action. Ceramide can induce death of cancer cells by decreasing glutathione levels, and in our work it induced dose- and time-dependent depletion of glutathione in P. falciparum parasites. N-acetylcysteine, a precursor of glutathione, abrogated the cytotoxic effect of ceramide. Thus, ceramide can mediate growth inhibition of P. falciparum parasites by decreasing glutathione levels. The antimalarial drugs artemisinin and mefloquine induced the death of P. falciparum parasites by sphingomyelinase-generated ceramide and by decreasing parasite glutathione levels. Altogether, ceramide was identified as a signalling molecule capable of inducing growth inhibition of P. falciparum malarial parasites.
Url:
DOI: 10.1007/s000180300049
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B73
- to stream Istex, to step Curation: 000B73
- to stream Istex, to step Checkpoint: 000F59
- to stream Main, to step Merge: 002142
- to stream Main, to step Curation: 002123
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ceramide mediates growth inhibition of the Plasmodium falciparum parasite</title><author><name sortKey="Pankova Kholmyansky, I" sort="Pankova Kholmyansky, I" uniqKey="Pankova Kholmyansky I" first="I." last="Pankova-Kholmyansky">I. Pankova-Kholmyansky</name></author><author><name sortKey="Dagan, A" sort="Dagan, A" uniqKey="Dagan A" first="A." last="Dagan">A. Dagan</name></author><author><name sortKey="Gold, D" sort="Gold, D" uniqKey="Gold D" first="D." last="Gold">D. Gold</name></author><author><name sortKey="Zaslavsky, Z" sort="Zaslavsky, Z" uniqKey="Zaslavsky Z" first="Z." last="Zaslavsky">Z. Zaslavsky</name></author><author><name sortKey="Skutelsky, E" sort="Skutelsky, E" uniqKey="Skutelsky E" first="E." last="Skutelsky">E. Skutelsky</name></author><author><name sortKey="Gatt, S" sort="Gatt, S" uniqKey="Gatt S" first="S." last="Gatt">S. Gatt</name></author><author><name sortKey="Flescher, E" sort="Flescher, E" uniqKey="Flescher E" first="E." last="Flescher">E. Flescher</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:86B8F793BB881BF9EFC51B1984CE0313F0190AA5</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1007/s000180300049</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-BLJJGV0C-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000B73</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B73</idno><idno type="wicri:Area/Istex/Curation">000B73</idno><idno type="wicri:Area/Istex/Checkpoint">000F59</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F59</idno><idno type="wicri:doubleKey">1420-682X:2003:Pankova Kholmyansky I:ceramide:mediates:growth</idno><idno type="wicri:Area/Main/Merge">002142</idno><idno type="wicri:Area/Main/Curation">002123</idno><idno type="wicri:Area/Main/Exploration">002123</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ceramide mediates growth inhibition of the Plasmodium falciparum parasite</title><author><name sortKey="Pankova Kholmyansky, I" sort="Pankova Kholmyansky, I" uniqKey="Pankova Kholmyansky I" first="I." last="Pankova-Kholmyansky">I. Pankova-Kholmyansky</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel), Fax: + 972 3 640 9160, e-mail: flascher@post.tau.ac.il</wicri:cityArea></affiliation></author><author><name sortKey="Dagan, A" sort="Dagan, A" uniqKey="Dagan A" first="A." last="Dagan">A. Dagan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Biochemistry, Hebrew University-Hadassah School of Medicine, Jerusalem 91120 (Israel)</wicri:cityArea></affiliation></author><author><name sortKey="Gold, D" sort="Gold, D" uniqKey="Gold D" first="D." last="Gold">D. Gold</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel), Fax: + 972 3 640 9160, e-mail: flascher@post.tau.ac.il</wicri:cityArea></affiliation></author><author><name sortKey="Zaslavsky, Z" sort="Zaslavsky, Z" uniqKey="Zaslavsky Z" first="Z." last="Zaslavsky">Z. Zaslavsky</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Interdepartmental Core Facility, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel)</wicri:cityArea></affiliation></author><author><name sortKey="Skutelsky, E" sort="Skutelsky, E" uniqKey="Skutelsky E" first="E." last="Skutelsky">E. Skutelsky</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel)</wicri:cityArea></affiliation></author><author><name sortKey="Gatt, S" sort="Gatt, S" uniqKey="Gatt S" first="S." last="Gatt">S. Gatt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Biochemistry, Hebrew University-Hadassah School of Medicine, Jerusalem 91120 (Israel)</wicri:cityArea></affiliation></author><author><name sortKey="Flescher, E" sort="Flescher, E" uniqKey="Flescher E" first="E." last="Flescher">E. Flescher</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel), Fax: + 972 3 640 9160, e-mail: flascher@post.tau.ac.il</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cellular and Molecular Life Sciences CMLS</title><title level="j" type="abbrev">CMLS, Cell. Mol. Life Sci.</title><idno type="ISSN">1420-682X</idno><idno type="eISSN">1420-9071</idno><imprint><publisher>Birkhäuser Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="2003-03-01">2003-03-01</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="577">577</biblScope><biblScope unit="page" to="587">587</biblScope></imprint><idno type="ISSN">1420-682X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1420-682X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Key words. Malaria; ceramide; glutathione; parasite growth; artemisinin; mefloquine.</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract.: In mammalian cells, ceramide mediates death by chemotherapeutic drugs. We analysed, for the first time, the role of ceramide in inhibiting growth of the malaria-causing parasite Plasmodium falciparum. Added exogenously, ceramide significantly decreased the number of parasites, and this effect was abolished by sphingosine-1-phosphate, a biological antagonist of ceramide action. Ceramide can induce death of cancer cells by decreasing glutathione levels, and in our work it induced dose- and time-dependent depletion of glutathione in P. falciparum parasites. N-acetylcysteine, a precursor of glutathione, abrogated the cytotoxic effect of ceramide. Thus, ceramide can mediate growth inhibition of P. falciparum parasites by decreasing glutathione levels. The antimalarial drugs artemisinin and mefloquine induced the death of P. falciparum parasites by sphingomyelinase-generated ceramide and by decreasing parasite glutathione levels. Altogether, ceramide was identified as a signalling molecule capable of inducing growth inhibition of P. falciparum malarial parasites.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Pankova Kholmyansky, I" sort="Pankova Kholmyansky, I" uniqKey="Pankova Kholmyansky I" first="I." last="Pankova-Kholmyansky">I. Pankova-Kholmyansky</name></region><name sortKey="Dagan, A" sort="Dagan, A" uniqKey="Dagan A" first="A." last="Dagan">A. Dagan</name><name sortKey="Flescher, E" sort="Flescher, E" uniqKey="Flescher E" first="E." last="Flescher">E. Flescher</name><name sortKey="Gatt, S" sort="Gatt, S" uniqKey="Gatt S" first="S." last="Gatt">S. Gatt</name><name sortKey="Gold, D" sort="Gold, D" uniqKey="Gold D" first="D." last="Gold">D. Gold</name><name sortKey="Skutelsky, E" sort="Skutelsky, E" uniqKey="Skutelsky E" first="E." last="Skutelsky">E. Skutelsky</name><name sortKey="Zaslavsky, Z" sort="Zaslavsky, Z" uniqKey="Zaslavsky Z" first="Z." last="Zaslavsky">Z. Zaslavsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002123 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002123 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:86B8F793BB881BF9EFC51B1984CE0313F0190AA5
|texte= Ceramide mediates growth inhibition of the Plasmodium falciparum parasite
}}
| This area was generated with Dilib version V0.6.33. |  |